The average age of the world's population is rising due to an increase in excellent health care, a greater desire for optimal health, and an interest in total well-being. According to the World Health Organization (WHO), the number of people over the age of 60 will more than double by 2050.
While there are several advantages to living in old age, the incidence of chronic age-related disorders has also increased. Because of the rise in lifespan, many people are looking for healthy ways to assist the aging process.
Senolytic pills have grown in popularity as people seek a better approach to aging. What exactly are senolytic supplements? Do they promote a healthy aging process? If so, how so?
What Exactly Are Senolytic Supplements?
The name senolytic, which means "old destroying," has lately been used to refer to a family of chemicals that aid in the healthy aging process. As a result, senolytic supplements are nutrient-rich compounds that are often used to treat or prevent age-related sickness and disease.
According to mouse studies, senolytic supplements may potentially help lengthen longevity.
When it comes to how senolytic supplements operate, most research indicates that they do so in a number of ways. Senolytic supplements function primarily by targeting senescent cells. Senescent cells are old or aging cells in the body that no longer function correctly.
Cells can become senescent or elderly as a result of cellular damage, cancer-promoting genes, DNA damage, or telomere shortening.
Senescent cells may congregate in the body as it ages. These cells then stop reproducing and resist apoptosis. Apoptosis is a natural process in which old cells are designed to die in order for new cells to replace them.
Senescent or "zombie" cells that refuse to die may emit toxic proteins that exacerbate inflammation, tissue damage, chronic sickness, and disease. According to some studies, a buildup of senescent cells is responsible for a wide range of disorders. Heart disease, metabolic failure, renal illness, malignancies, and even weakness in old age have all been related to senescent "zombie" cells. According to research, senolytic supplements may aid in the reduction of senescent cells.
Here are six senolytic supplements to help you age well.
Fisetin
In terms of senolytics, fisetin is one of the most powerful heavy hitters that can be found. Fisetin is a flavonoid, a naturally occurring chemical present in a variety of fruits and vegetables.
Strawberries, apples, tomatoes, and cucumbers are all rich in fisetin.
According to research, fisetin may have a potent senolytic effect.
In one investigation, human adipose or fatty tissue was utilized to investigate the efficacy of fisetin as a senolytic. The study discovered that fisetin was capable of destroying zombie-like senescent cells in human adipose tissue, resulting in a decrease in senescent cells overall.
The researchers next put fisetin to the test in elderly mice. The study revealed that fisetin supplementation might lengthen the lifespan of mice while restoring organ homeostasis and minimizing age-related diseases.
Fisetin may possibly work as an anti-inflammatory agent, according to research. Fisetin inhibited the release of inflammatory cytokines or cell messengers in one test-tube study.
Fisetin may be a powerhouse when it comes to promoting good aging, having the ability to help in the reduction of zombie cells as well as significant anti-inflammatory effects.
Apigenin
Apigenin, like fisetin, is a flavonoid found in foods such as parsley, celery, artichokes, and chamomile.
Apigenin appears to be a potent senolytic supplement, according to research. According to one test-tube investigation, apigenin can prevent senescent cells from secreting toxic proteins.
Senescent cells' toxic proteins may not only lead to an increase in inflammation. According to research, the proteins released by senescent cells may transform healthy cells into zombie cells.
According to research, apigenin is an effective anti-oxidant because it helps the body produce more glutathione.
Glutathione is widely regarded as the body's main antioxidant. Glutathione is critical in protecting cells from oxidative damage. It also helps to protect cells from toxicity caused by external chemicals, such as drugs.
As we age, our bodies generate less glutathione, potentially increasing oxidative stress.
Quinine
When it comes to working as a senolytic vitamin, quercetin is another powerful hitter. Quercetin, like fisetin and apigenin, is a naturally occurring flavonoid. Onions, broccoli, apples, and cherries are examples of foods high in quercetin.
There will be one open-label phase. A pilot study utilizing quercetin and a pharmaceutical medication monitored nine people with diabetes-related renal impairment.
These nine participants were males and females, ranging in age from 68 to 71. The participants in the research were given quercetin and the pharmaceutical dasatinib for three days, and the number of senescent cells in fatty tissues was assessed before and after an 11-day gap.
The study discovered that the combination of quercetin and pharmaceuticals significantly decreased the number of senescent cells in fatty tissue. The study also discovered that the quercetin and pharmaceutical combination performed as an anti-inflammatory agent by lowering inflammatory cell messenger production.
According to one study, quercetin supplementation may also be beneficial to the heart by avoiding age-related heart failure.
Curcumin
Curcumin is the principal physiologically active ingredient of turmeric, the golden spice. Curcumin has been proven in recent research to have a wide range of health-promoting qualities, including serving as a potent anti-inflammatory and anti-cancer agent.
Curcumin may also be an excellent senolytic, according to research. Curcumin has been shown in animal experiments to have anti-oxidant properties that may lead to an increase in life span.
Curcumin supplementation was observed to enhance the average life span of Wistar rats by nearly 40% in one animal study.
Curcumin treatment extended the maximum lifespan of the roundworm Caenorhabditis elegans by more than 20% in another animal study. C. elegans typically lives between 12 and 18 days. The study found that taking a curcumin pill increased the longevity of roundworms by more than three days.
Curcumin may prolong longevity by raising the activity of an enzyme that promotes healthy telomere lengths, according to research. Telomeres are the DNA ends. They become shorter as they get older.
Telomere length reduction has been linked to an increase in age-related disorders and a shorter lifespan.
Thistle (milk thistle)
Silybum marianum, often known as milk thistle, is a strong senolytic supplement that is showing encouraging outcomes. Milk thistle is a plant that is linked to the daisy family. Milk thistle is a Mediterranean native that is now utilized all over the world.
This extraordinary plant is frequently used to improve liver and gallbladder health, but research shows that it may also function as a senolytic supplement. One test-tube investigation involves adding milk thistle extract to senescent human skin cells.
According to the study, senescent skin cells inhibited the development and proliferation of younger skin cells. Normal skin cells became zombie-like as a result of the senescent cells.
The study discovered that milk thistle extract might remove senescent skin cells while increasing the development of younger skin cells. According to the findings, milk thistle may be able to regenerate skin cells and prevent premature aging.
Milk thistle, in addition to its putative senolytic qualities, appears to be a remarkable antioxidant with a wide range of advantages, ranging from boosting metabolism to aiding in the maintenance of healthy blood pressure.
EGCG (Epigallo-Catechin-Gallate)
EGCG, or epigallo-catechin-gallate, may aid in the healthy aging process.
Green tea contains a flavonoid known as EGCG. For years, it has been associated with optional health in many medical systems. According to research, EGCG may have some senolytic action. In one test-tube investigation, EGCG was reported to help alleviate mitochondrial dysfunction by stimulating new mitochondrial growth.
The mitochondria are the cell's powerhouse. They generate the energy required for the body to function.
Mitochondrial function declines with age, resulting in decreased energy and weakness.
According to research, EGCG may also promote healthy aging by functioning as an antioxidant. According to one test-tube investigation, EGCG can boost the production of longevity-promoting proteins by lowering oxidative stress.
EGCG may also have potent anti-inflammatory and anti-tumor effects.
Senolytic supplements are amazing substances that may aid in the promotion of healthy aging by killing zombie cells in the body. According to research, many natural senolytics may also have wonderful features, such as working as an anti-inflammatory or an anti-oxidant.
Including senolytic pills in a healthy aging, regimen may improve lifespan and maximum wellness for many years to come.
While some of us look for reindeer in the skies on Christmas Eve, others look for snow. Ultimately, the enchantment and joy of the holidays stem from the sparkling snowflakes and the serene expanse of pristine white on the earth.
We wanted to grant your desire to have a white Christmas this holiday season. Even with the assistance of some very special elves, we are unable to control the weather, but we can tell you that in the USA, the finest spots to spend Christmas are when there's a decent probability of snowfall, either on the ground or in the sky.
Oh, how much fun it is to get into the holiday spirit with our recommendations! Take a vacation to one of these snowy wonderlands over the Christmas season!
1. Aspen, Colorado
Aspen promises you a happy little Christmas with a 100 percent likelihood of snowfall and an almost flawless white Christmas record.
At Ullr Nights, honor the Norse God of Snow with snow tubing, bonfires, and Ullr's ghost ship.
Twelve Days of Aspen is a countdown to Christmas, with festivities taking place around the area.
Join the carolers at Base Village and Snowmass Mall's Santa's Village.
2. Lake Placid, New York
December brings an average of 23 inches of snow to Lake Placid, increasing the likelihood of a chilly Christmas in the Adirondacks. It makes sense that it's among the top destinations for Christmas tourism.
Observe how Main Street decks the halls by taking part in the village stroll.
Get a free lift ticket at Whiteface Mountain by dressing like Santa.
At the Olympic Sports Complex, brave the tracks in a bobsled.
3. Mammoth Lakes, California
Mammoth Lakes has average lows of 17 degrees Fahrenheit in December, which makes for perfect weather. Let there be snow—plenty and lots of it!
Enjoy the breathtaking Village Gondola ride during the Night of Lights while fireworks are displayed.
Join in the massive holiday celebrations.
Take the Tamarack XC Ski Center December Full Moon Snowshoe Tour.
4. Minneapolis-St. Paul, Minnesota
Given that there is snow on the ground three out of every four Christmases in the Twin Cities, the likelihood of flurries appears to be bright and cheerful.
Enjoy a visit with Santa and take in the lit artwork at Loring Park during Holidazzle.
Get in character as Kris Kringle at St. Paul Lowertown SantaCon.
See the decorations at the Minnesota Governor's Mansion during the holiday tour season.
Question. I find it unsettling that guidelines and suggestions for medicine seem to change so frequently. For instance, I recently read that recommendations for colon cancer screening may undergo yet another modification. How exactly does one determine what is right?
Answer. Different factors contribute to the occurrence of these changes. One explanation for this is that continuing studies yield fresh data that informs new recommendations. An additional concern pertains to divergent expert opinions. As you correctly noted, this is exemplified by the controversy surrounding the optimal age to initiate colon cancer screening for individuals with an average risk profile this year.
A considerable number of clinicians, including myself, adhere to the recommendations put forth by the U.S. Preventive Services Task Force (USPSTF). The USPSTF enlists sixteen specialists from various fields to conduct research and discussion on the potential advantages and disadvantages of screening and other preventive and health-promoting techniques for each guideline. The summary recommendation is subsequently made available for public feedback.
A considerable number of clinicians, including myself, adhere to the recommendations put forth by the U.S. Preventive Services Task Force (USPSTF). The USPSTF enlists sixteen specialists from various fields to conduct research and discussion on the potential advantages and disadvantages of screening and other preventive and health-promoting techniques for each guideline. The summary recommendation is subsequently made available for public feedback.
Question. I'm a 73-year-old male with heart disease (I had coronary bypass surgery at the age of 45). I pay special attention to my health and exercise on a regular basis. I went to the ER recently because I was experiencing chest discomfort. Despite the fact that my electrocardiogram and, subsequently, a stress echocardiography revealed no issues, my troponin levels were high, ranging from 57 to 63 ng/L on multiple repeated tests. Should I be concerned about the increased troponin? Is it possible to reduce this level?
Answer. Troponins, which are proteins that help muscles contract, are almost exclusively present in heart and skeletal muscle cells. Reduced blood flow during a heart attack destroys sections of the heart muscle, causing troponins to be released into the circulation. That's why emergency department doctors frequently assess blood troponin levels in individuals who are having a heart attack.
The first tests found troponins that are exclusive to cardiac cells, as well as two subtypes of the protein: troponin T and troponin I. Newer versions of the tests identify extremely tiny levels of troponins at 10 to 100 times higher concentrations than the initial test. High-sensitivity troponin testing can diagnose heart attacks sooner and more precisely.
The online publication of Menopause magazine on June 27, 2023, featured research that analyzed data from five previous studies with a sample size of over one million women. Notably, none of the participants had been diagnosed with GERD prior to the commencement of the study. A study conducted by researchers revealed a positive correlation between the utilization of hormone treatment for alleviating menopausal symptoms and the increased likelihood of developing gastroesophageal reflux disease (GERD).
GERD is a medical condition defined by symptoms such as heartburn, dysphagia, and chest pain. The incidence of gastroesophageal reflux disease (GERD) was shown to be 41% higher among women who received estrogen monotherapy, whereas those who had progesterone-only hormone therapy exhibited a 39% increased likelihood of developing GERD. The administration of a hormone therapy regimen comprising both estrogen and progesterone has been found to be associated with a 16% higher incidence rate of gastroesophageal reflux disease (GERD).
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The kiwifruit season starts in October and extends until May. The delectable verdant fruit is very suitable for use in salads, smoothies, and desserts. According to a tiny randomized experiment, there is a possibility that it may provide an additional benefit in relieving persistent constipation. According to the researchers' instructions, a group of over 180 adults from Italy, Japan, and New Zealand, both with and without constipation, participated in two consecutive four-week treatment regimens. They consumed two peeled kiwifruits a day as part of one program.
There are several educational initiatives available to enhance one's driving proficiency. These programs aim to improve individuals' abilities and knowledge of operating motor vehicles safely and effectively.
There is an increasing need for caution while driving. According to recent data provided by the National Highway Traffic Safety Administration, there has been a consistent upward trend in road fatalities among individuals aged 65 and over inside the United States. Although there was a minor decline in the figures during the pandemic quarantine in 2020, they more than compensated for that with a 14% increase in 2021. Regardless of whether one plans to go on a trip to a local grocery shop, attend a festive party, or seek a more temperate environment during the winter season, it is essential to prioritize the practice of safe driving. Several different sorts of applications are available that can assist in accomplishing that task.
The purpose of this study is to conduct evaluations of Car-Fit, a program designed to assess the compatibility between drivers and their vehicles.
As individuals advance in age, they may have challenges accessing the gas and stop pedals, as well as maintaining a clear line of sight above the dashboard. This phenomenon may be attributed to the individual experiencing a decrease in physical dimensions as a result of the aging process or a lack of familiarity with the advanced technological features of the vehicle that are designed to customize the user's comfort.
The utilization of a software application known as Car-Fit can provide assistance in this matter. This assessment is conducted by AAA, AARP, and the American Occupational Therapy Association with the primary objective of enhancing your vehicle's ergonomic suitability. Individuals have the option to participate in a Car-Fit event conducted in person, or alternatively, they can choose to access a session through an online platform.
The purpose of this study is to conduct evaluations of Car-Fit, a program designed to assess the compatibility between drivers and their vehicles.
As individuals advance in age, they may have challenges accessing the gas and stop pedals, as well as maintaining a clear line of sight above the dashboard. This phenomenon may be attributed to the individual experiencing a decrease in physical dimensions as a result of the aging process or a lack of familiarity with the advanced technological features of the vehicle that are designed to customize the user's comfort.
The utilization of a software application known as Car-Fit can provide assistance in this matter. This assessment is conducted by AAA, AARP, and the American Occupational Therapy Association with the primary objective of enhancing your vehicle's ergonomic suitability. Individuals have the option to participate in a Car-Fit event conducted in person, or alternatively, they can choose to access a session through an online platform.
If you've ever had diarrhea, you are aware of how fast it wears you out. Imagine a case that drags on forever or reappears repeatedly.
This is the situation for over 500,000 Americans who contract the bacterial infection known as Clostridioides difficile, or C. diff., annually. Life-threatening conditions include violent diarrhea and intestinal inflammation.
You'll learn about the typical symptoms, how C. diff spreads and produces toxins, and who is most susceptible from this overview.
C. diff spreads in what way?
We have C. diff in our feces, just like many other bacteria do. Almost everyone carries it; it's on our skin and even on the bottoms of our shoes. The C. diff bacteria are dormant spores while they are outside the body. Their sole opportunity to come into action is when they are ingested and make it to the intestines.
Many people who ingest C. diff spores never get sick, even in that case. The only individuals who feel ill from the spores are those whose gut microbiome, or the billions of microorganisms that reside in their intestines, becomes unbalanced for any of the several causes listed below. The spores begin to grow and produce toxins when an imbalance takes place, which results in a C. diff infection.
C. diff bacteria colonize many of us with no negative effects. Spores of Candida diff are continuously ingested by us. It is only in certain situations that the spores will sprout and emit poison. The toxin is the cause of your illness.
What signs indicate an infection with C. diff?
The symptoms bear similarities to several different forms of digestive problems. This might initially make it challenging to distinguish the infection from less serious conditions.
Signs to look out for include
persistent diarrhea that lasts for three days or longer
nausea, fever, discomfort or pain in the stomach, or loss of appetite.
Although there is no need for the general public to be afraid of C. diff, if you are prescribed an antibiotic, watch out for signs of diarrhea after the medication has finished. When you stop taking the antibiotic, the diarrhea that is related to the drug alone should go away.
Who is most at risk?
From the Centers for Disease Control (CDC), here are some frightening statistics:
The most common cause of illnesses linked to healthcare in the US is C. diff.
It disproportionately affects residents of nursing homes and hospitals.
One in eleven adults over 65 who are diagnosed with a C. diff illness related to medical treatment pass away within a month.
Nonetheless, the illness can also affect other populations. While C. diff infections linked to healthcare facilities are leveling off, infections that affect the general public and are referred to as community-based are rising.
Life and your house are once again all about you after decades of child juggling. An empty nest conjures up images of travel and quality time with grandkids for a lot of individuals in their 50s and 60s, as well as ideas of relocating to make the most of their next stage of life.
However, looking for a home later in life also presents a different set of factors. Your requirements have changed; for example, you could need less room and maintenance. Your capabilities have also probably changed. Now is the time to think about what architectural elements can turn your new house into a forever home, one that will allow you to age in place should you lose your mobility or agility.
Maybe you believe that buying a house based on changes that might never happen is too conservative, especially if you're in good health and want to stay that way. However, Harvard experts believe it's wise to adopt this perspective now, before a domestic catastrophe jeopardizes your freedom, because change is the only constant in life.
Do you wish to age in place? Tap technology
For almost 75 percent of older people, staying in one's home and community while aging in place is still ideal. According to a recent survey, over half of older people utilize assistive technology like fitness trackers and health apps to achieve this goal.
In a May 2023 publication, U.S. News and World Report conducted a study of 2,000 Americans aged 55 and above, of whom 53% were women. Of those surveyed, 53% said they used assistive technology. Mobile applications with a medical or health theme ranked highest in usage (25%), followed by wearable medical alert monitors (17%), smart home appliances (that regulate lighting, temperature, and other aspects), hearing aids, and shopping or meal delivery apps. According to the overwhelming majority of study participants, assistive technologies enhance their quality of life by making them feel safer (44%), healthier (33%), more independent (55%), and more mobile (20%).
Some older folks are so devoted to the concept of aging in place that they'll probably continue to live in less-than-ideal environments. This divide can be closed with the use of assistive technology, but only if it is fully utilized.
A wide range of early warning systems may be found in wearable medical alert trackers, and it is essential to acknowledge and respond to any notifications received from these devices regarding possible hazards. This presents a chance to utilize the aforementioned knowledge in order to establish communication with either one's family or healthcare provider, therefore seeking assistance to strengthen one's defenses.
Perhaps you are impressed by your partner's consistency and notice that he uses the restroom after drinking a cup of coffee every morning. Possibly, you do not share with that much frequency and are uncertain whether you ought to.
However, what exactly does maintaining a regular schedule entail? Various factors influence an individual's response, including but not limited to age, dietary habits, level of physical activity, daily schedule, and hydration status.
Although the frequency of bowel movements is inconsequential, it is critical that the pattern remain relatively regular and that you experience comfort. With regular and healthy bowel movements, you will also experience complete cleansing of the rectum without experiencing discomfort or pain and without exerting excessive effort to complete the task.
Identifying a problem begins with recognizing a significant deviation from your usual routine. For instance, if you normally experience one gastrointestinal movement per day but find yourself having them only once per week with no apparent explanation, you should consult a medical professional. Having additional symptoms, including but not limited to fatigue, pain, unintended weight loss, blood in the stool, or a change in stool consistency, further emphasizes the urgency of that visit.
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