The average age of the world's population is rising due to an increase in excellent health care, a greater desire for optimal health, and an interest in total well-being. According to the World Health Organization (WHO), the number of people over the age of 60 will more than double by 2050.
While there are several advantages to living in old age, the incidence of chronic age-related disorders has also increased. Because of the rise in lifespan, many people are looking for healthy ways to assist the aging process.
Senolytic pills have grown in popularity as people seek a better approach to aging. What exactly are senolytic supplements? Do they promote a healthy aging process? If so, how so?
What Exactly Are Senolytic Supplements?
The name senolytic, which means "old destroying," has lately been used to refer to a family of chemicals that aid in the healthy aging process. As a result, senolytic supplements are nutrient-rich compounds that are often used to treat or prevent age-related sickness and disease.
According to mouse studies, senolytic supplements may potentially help lengthen longevity.
When it comes to how senolytic supplements operate, most research indicates that they do so in a number of ways. Senolytic supplements function primarily by targeting senescent cells. Senescent cells are old or aging cells in the body that no longer function correctly.
Cells can become senescent or elderly as a result of cellular damage, cancer-promoting genes, DNA damage, or telomere shortening.
Senescent cells may congregate in the body as it ages. These cells then stop reproducing and resist apoptosis. Apoptosis is a natural process in which old cells are designed to die in order for new cells to replace them.
Senescent or "zombie" cells that refuse to die may emit toxic proteins that exacerbate inflammation, tissue damage, chronic sickness, and disease. According to some studies, a buildup of senescent cells is responsible for a wide range of disorders. Heart disease, metabolic failure, renal illness, malignancies, and even weakness in old age have all been related to senescent "zombie" cells. According to research, senolytic supplements may aid in the reduction of senescent cells.
Here are six senolytic supplements to help you age well.
Fisetin
In terms of senolytics, fisetin is one of the most powerful heavy hitters that can be found. Fisetin is a flavonoid, a naturally occurring chemical present in a variety of fruits and vegetables.
Strawberries, apples, tomatoes, and cucumbers are all rich in fisetin.
According to research, fisetin may have a potent senolytic effect.
In one investigation, human adipose or fatty tissue was utilized to investigate the efficacy of fisetin as a senolytic. The study discovered that fisetin was capable of destroying zombie-like senescent cells in human adipose tissue, resulting in a decrease in senescent cells overall.
The researchers next put fisetin to the test in elderly mice. The study revealed that fisetin supplementation might lengthen the lifespan of mice while restoring organ homeostasis and minimizing age-related diseases.
Fisetin may possibly work as an anti-inflammatory agent, according to research. Fisetin inhibited the release of inflammatory cytokines or cell messengers in one test-tube study.
Fisetin may be a powerhouse when it comes to promoting good aging, having the ability to help in the reduction of zombie cells as well as significant anti-inflammatory effects.
Apigenin
Apigenin, like fisetin, is a flavonoid found in foods such as parsley, celery, artichokes, and chamomile.
Apigenin appears to be a potent senolytic supplement, according to research. According to one test-tube investigation, apigenin can prevent senescent cells from secreting toxic proteins.
Senescent cells' toxic proteins may not only lead to an increase in inflammation. According to research, the proteins released by senescent cells may transform healthy cells into zombie cells.
According to research, apigenin is an effective anti-oxidant because it helps the body produce more glutathione.
Glutathione is widely regarded as the body's main antioxidant. Glutathione is critical in protecting cells from oxidative damage. It also helps to protect cells from toxicity caused by external chemicals, such as drugs.
As we age, our bodies generate less glutathione, potentially increasing oxidative stress.
Quinine
When it comes to working as a senolytic vitamin, quercetin is another powerful hitter. Quercetin, like fisetin and apigenin, is a naturally occurring flavonoid. Onions, broccoli, apples, and cherries are examples of foods high in quercetin.
There will be one open-label phase. A pilot study utilizing quercetin and a pharmaceutical medication monitored nine people with diabetes-related renal impairment.
These nine participants were males and females, ranging in age from 68 to 71. The participants in the research were given quercetin and the pharmaceutical dasatinib for three days, and the number of senescent cells in fatty tissues was assessed before and after an 11-day gap.
The study discovered that the combination of quercetin and pharmaceuticals significantly decreased the number of senescent cells in fatty tissue. The study also discovered that the quercetin and pharmaceutical combination performed as an anti-inflammatory agent by lowering inflammatory cell messenger production.
According to one study, quercetin supplementation may also be beneficial to the heart by avoiding age-related heart failure.
Curcumin
Curcumin is the principal physiologically active ingredient of turmeric, the golden spice. Curcumin has been proven in recent research to have a wide range of health-promoting qualities, including serving as a potent anti-inflammatory and anti-cancer agent.
Curcumin may also be an excellent senolytic, according to research. Curcumin has been shown in animal experiments to have anti-oxidant properties that may lead to an increase in life span.
Curcumin supplementation was observed to enhance the average life span of Wistar rats by nearly 40% in one animal study.
Curcumin treatment extended the maximum lifespan of the roundworm Caenorhabditis elegans by more than 20% in another animal study. C. elegans typically lives between 12 and 18 days. The study found that taking a curcumin pill increased the longevity of roundworms by more than three days.
Curcumin may prolong longevity by raising the activity of an enzyme that promotes healthy telomere lengths, according to research. Telomeres are the DNA ends. They become shorter as they get older.
Telomere length reduction has been linked to an increase in age-related disorders and a shorter lifespan.
Thistle (milk thistle)
Silybum marianum, often known as milk thistle, is a strong senolytic supplement that is showing encouraging outcomes. Milk thistle is a plant that is linked to the daisy family. Milk thistle is a Mediterranean native that is now utilized all over the world.
This extraordinary plant is frequently used to improve liver and gallbladder health, but research shows that it may also function as a senolytic supplement. One test-tube investigation involves adding milk thistle extract to senescent human skin cells.
According to the study, senescent skin cells inhibited the development and proliferation of younger skin cells. Normal skin cells became zombie-like as a result of the senescent cells.
The study discovered that milk thistle extract might remove senescent skin cells while increasing the development of younger skin cells. According to the findings, milk thistle may be able to regenerate skin cells and prevent premature aging.
Milk thistle, in addition to its putative senolytic qualities, appears to be a remarkable antioxidant with a wide range of advantages, ranging from boosting metabolism to aiding in the maintenance of healthy blood pressure.
EGCG (Epigallo-Catechin-Gallate)
EGCG, or epigallo-catechin-gallate, may aid in the healthy aging process.
Green tea contains a flavonoid known as EGCG. For years, it has been associated with optional health in many medical systems. According to research, EGCG may have some senolytic action. In one test-tube investigation, EGCG was reported to help alleviate mitochondrial dysfunction by stimulating new mitochondrial growth.
The mitochondria are the cell's powerhouse. They generate the energy required for the body to function.
Mitochondrial function declines with age, resulting in decreased energy and weakness.
According to research, EGCG may also promote healthy aging by functioning as an antioxidant. According to one test-tube investigation, EGCG can boost the production of longevity-promoting proteins by lowering oxidative stress.
EGCG may also have potent anti-inflammatory and anti-tumor effects.
Senolytic supplements are amazing substances that may aid in the promotion of healthy aging by killing zombie cells in the body. According to research, many natural senolytics may also have wonderful features, such as working as an anti-inflammatory or an anti-oxidant.
Including senolytic pills in a healthy aging, regimen may improve lifespan and maximum wellness for many years to come.
Experience the Magic of a White Christmas: Top U.S. Destinations for Snowy Holidays
While some of us search for reindeer in the skies on Christmas Eve, others eagerly await the first snowfall. The enchantment and joy of the holiday season truly come alive with sparkling snowflakes and the serene beauty of a pristine white landscape.
If you're dreaming of a white Christmas this year, we’ve got you covered! While we can't control the weather (even with the help of some special elves), we can share the best U.S. destinations where you're most likely to find that magical snowfall—whether it’s covering the ground or gently falling from the sky.
Get ready to embrace the holiday spirit and create unforgettable memories in these snowy wonderlands this Christmas season!
1. Aspen, Colorado
Aspen promises you a joyful little Christmas with a 100 percent likelihood of snowfall and an almost flawless white Christmas record.
At Ullr Nights, honor the Norse God of Snow with snow tubing, bonfires, and Ullr's ghost ship.
Twelve Days of Aspen is a countdown to Christmas, with festivities taking place around the area.
Join the carolers at Base Village and Snowmass Mall's Santa's Village.
2. Lake Placid, New York
December brings an average of 23 inches of snow to Lake Placid, increasing the likelihood of a chilly Christmas in the Adirondacks. It makes sense that it's among the top destinations for Christmas tourism.
Observe how Main Street decks the halls by participating in the village stroll.
Get a free lift ticket at Whiteface Mountain by dressing like Santa.
At the Olympic Sports Complex, brave the tracks in a bobsled.
3. Mammoth Lakes, California
Mammoth Lakes has average lows of 17 degrees Fahrenheit in December, which makes for perfect weather. Let there be snow—plenty and lots of it!
Take in the breathtaking Village Gondola ride as fireworks light up the night.
Join in the massive holiday celebrations.
Take the Tamarack XC Ski Center December Full Moon Snowshoe Tour.
4. Minneapolis-St. Paul, Minnesota
Since the Twin Cities receive snow three out of four Christmases, flurries seem likely.
Enjoy a visit with Santa and take in the lit artwork at Loring Park during Holidazzle.
Get in character as Kris Kringle at St. Paul Lowertown SantaCon.
See the decorations at the Minnesota Governor's Mansion during the holiday tour season.
5. Anchorage, Alaska
Go to Anchorage if you want to see the ground blanketed with snow when you wake up on Christmas morning. There have been 31 straight snowy Christmases in this city!
Take a stroll around the Zoo Lights-lit animal exhibits at the Alaska Zoo.
Take in the ice formations at Holiday Lights in the Garden while sipping hot chocolate.
Curl up inside and enjoy "A Christmas Carol" at the Alaska Center for the Performing Arts.
6. Jackson Hole, Wyoming
Jackson Hole's December temperatures can drop as low as 7 degrees Fahrenheit, fulfilling your dream of a snowy Christmas. Embrace the festive spirit.
On Christmas Eve, look out for Santa as he skis the slopes at Jackson Hole Mountain Resort.
At Wort Hotel's 12 Days of Christmas, decorate cookies and sport your craziest holiday sweater.
Enjoy some festive fare while circling the Teton Village Ice Rink.
7. Lake Tahoe, California
It usually gets as low as 24 degrees F in Lake Tahoe, so keep shaking that snow globe! A fresh layer of snow transforms Tahoe into a whimsical Christmas scene.
Take a trip on a Borges sleigh and trot along the route that connects the village and Merry Wonderland.
Warm up indoors and see Olympic Village Lodge's production of "Twisted Nutcracker and the Tale of the Rat King.
Enjoy the festivities at the Heavenly Holidays Family Festival.
Depositphotos
Question. I find it unsettling that guidelines and suggestions for medicine seem to change so frequently. For instance, I recently read that recommendations for colon cancer screening may undergo yet another modification. How exactly does one determine what is right?
Answer. Different factors contribute to the occurrence of these changes. One explanation for this is that continuing studies yield fresh data that informs new recommendations. An additional concern pertains to divergent expert opinions. As you correctly noted, this is exemplified by the controversy surrounding the optimal age to initiate colon cancer screening for individuals with an average risk profile this year.
A considerable number of clinicians, including myself, adhere to the recommendations put forth by the U.S. Preventive Services Task Force (USPSTF). The USPSTF enlists sixteen specialists from various fields to conduct research and discussion on the potential advantages and disadvantages of screening and other preventive and health-promoting techniques for each guideline. The summary recommendation is subsequently made available for public feedback.
A considerable number of clinicians, including myself, adhere to the recommendations put forth by the U.S. Preventive Services Task Force (USPSTF). The USPSTF enlists sixteen specialists from various fields to conduct research and discussion on the potential advantages and disadvantages of screening and other preventive and health-promoting techniques for each guideline. The summary recommendation is subsequently made available for public feedback.
Question. I'm a 73-year-old male with heart disease (I had coronary bypass surgery at the age of 45). I pay special attention to my health and exercise on a regular basis. I went to the ER recently because I was experiencing chest discomfort. Despite the fact that my electrocardiogram and, subsequently, a stress echocardiography revealed no issues, my troponin levels were high, ranging from 57 to 63 ng/L on multiple repeated tests. Should I be concerned about the increased troponin? Is it possible to reduce this level?
Answer. Troponins, which are proteins that help muscles contract, are almost exclusively present in heart and skeletal muscle cells. Reduced blood flow during a heart attack destroys sections of the heart muscle, causing troponins to be released into the circulation. That's why emergency department doctors frequently assess blood troponin levels in individuals who are having a heart attack.
The first tests found troponins that are exclusive to cardiac cells, as well as two subtypes of the protein: troponin T and troponin I. Newer versions of the tests identify extremely tiny levels of troponins at 10 to 100 times higher concentrations than the initial test. High-sensitivity troponin testing can diagnose heart attacks sooner and more precisely.
The online publication of Menopause magazine on June 27, 2023, featured research that analyzed data from five previous studies with a sample size of over one million women. Notably, none of the participants had been diagnosed with GERD prior to the commencement of the study. A study conducted by researchers revealed a positive correlation between the utilization of hormone treatment for alleviating menopausal symptoms and the increased likelihood of developing gastroesophageal reflux disease (GERD).
GERD is a medical condition defined by symptoms such as heartburn, dysphagia, and chest pain. The incidence of gastroesophageal reflux disease (GERD) was shown to be 41% higher among women who received estrogen monotherapy, whereas those who had progesterone-only hormone therapy exhibited a 39% increased likelihood of developing GERD. The administration of a hormone therapy regimen comprising both estrogen and progesterone has been found to be associated with a 16% higher incidence rate of gastroesophageal reflux disease (GERD).
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