The FDA announced the long-awaited approval of Wegovy, a once-weekly injectable medication for weight reduction, on June 4, 2021.
In the months leading up to approval, Wegovy received a lot of media attention, with a New York Times story calling it a "game-changer," MedPage Today reporting "extraordinary outcomes," and the BBC claiming it may usher in a "new era" in obesity treatment. Wegovy's effectiveness has been lauded in the media as being superior to any other weight-loss drug now on the market. Such dramatic headlines are prevalent in the media, therefore we must examine if all of the media attention is actually justified.
What exactly is Wegovy and how does it function?
Semaglutide belongs to the glucagon-like peptide-1 receptor agonists or GLP-1 RAs, class of drugs. GLP-1 is a hormone that is produced spontaneously in the gastrointestinal system in response to food consumption. It has a number of effects, including boosting pancreatic insulin release, delaying stomach emptying, and reducing hunger via targeting brain receptors. This causes a feeling of satiety, or fullness, that lasts far longer than natural GLP-1 hormone levels.
Who can take Wegovy?
Nausea, diarrhoea, vomiting, and constipation are the most frequent adverse effects of Wegovy. The medicine also comes with a warning about the danger of a particular thyroid tumour, so it's not advised for anyone who has a personal or family history of medullary thyroid cancer or types 2 multiple endocrine neoplasias (a genetic condition associated with endocrine tumours). It's worth noting that tumours were only seen in animal studies and not in human trials.
How long can you take Wegovy?
In the months leading up to approval, Wegovy received a lot of media attention, with a New York Times story calling it a "game-changer," MedPage Today reporting "extraordinary outcomes," and the BBC claiming it may usher in a "new era" in obesity treatment. Wegovy's effectiveness has been lauded in the media as being superior to any other weight-loss drug now on the market. Such dramatic headlines are prevalent in the media, therefore we must examine if all of the media attention is actually justified.
What exactly is Wegovy and how does it function?
Wegovy is the brand name for semaglutide, a high-dose injectable peptide hormone molecule that was previously authorized by the FDA for the treatment of type 2 diabetes under the trade name Rybelsus (oral) and Ozempic (lower-dose injection). The higher-dose Wegovy allows for the better crossing of the blood-brain barrier, which increases its weight-loss efficacy. Injectable semaglutide eliminates the strict guidelines for ingesting on an empty stomach required by oral semaglutide, while the higher-dose Wegovy allows for the better crossing of the blood-brain barrier, which increases its weight-loss efficacy.
Who can take Wegovy?
Wegovy, like all other prescription obesity medicines, is authorized for use in those with a BMI of 30 kg/m2 or above, or those with a BMI of 27 kg/m2 with a weight-related medical condition such as high blood pressure, type 2 diabetes, or high cholesterol.
What are the disadvantages and advantages of Wegovy?
The STEP (Semaglutide Treatment Effect in People with Obesity) studies, Wegovy's phase 3 clinical trials, were undertaken in a number of clinical situations, each with small differences in the study population and research design. The STEP 1 study, whose findings were published in the New England Journal of Medicine, found that individuals allocated to the pharmaceutical group lost an average of 14.9 per cent of their body weight after 68 weeks of therapy, compared to only 2.4 per cent for those assigned to the placebo group. The average weight reduction seen with present anti-obesity medicines is generally about 5% to 9%, while individuals engaged in lifestyle lose an average of 3% to 5%.
How long can you take Wegovy?
Wegovy is one of six obesity medications presently authorized by the FDA for long-term use. As a result, it can be used indefinitely as long as it is effective for weight reduction and/or maintenance and does not cause unacceptable adverse effects. Exenatide was the first GLP-1 RA drug to get FDA approval in 2005; since then, numerous GLP-1 RAs have been authorized and have undertaken long-term studies proving either non-inferiority or superiority compared to placebo for severe adverse cardiovascular events including heart attacks and stroke. The SELECT study is a long-term cardiovascular outcomes trial for Wegovy, with the goal of determining the drug's impact on heart health.
Chelsey is a creative nail artist with attractive bold nails put together with vibrant colours and catchy characters. These are the cutest press on nails to try while the weather is still fluctuating.
Nine things that make a group chat active.
1. Learn to appreciate the posts of others, even if they are not your friends.
It gives them a sense of importance and encourages them to think about something more positive.
*2. In a group conversation, never run someone down on the platform.
You will drive them away and they will never express their objective viewpoints on topics.
*3. If you notice something from a member that you don't like, send them a private message.
Don't make a public assault on him/her on the platform.
*4. Never degrade or speak in a derogatory manner to members.
1/2 lb. spaghetti
1-pint cherry or grape tomatoes, sliced lengthwise seasoned with 1/2 tsp each kosher salt, pepper, oregano, garlic powder
1 tbsp olive oil for roasting
1 small yellow onion, finely chopped
2 tbsp olive oil
10 oz. mushrooms, very finely chopped
3/4 tsp each kosher salt, pepper, garlic powder
1 bell pepper, finely diced
3 cloves garlic, minced
1/2 cup reserved pasta cooking water
3 tbsp tomato paste
1/3 cup crushed tomatoes (canned)
1/2 15 oz. can chickpeas, drained and rinsed
1/4 cup fresh chopped parsley
2 cups (somewhat packed) baby spinach
2 tsp dried parsley
1/4 to 1/2 tsp red chilli flakes (to taste)
2 tsp lemon juice (optional)
1/4 to 1/3 cup coarsely chopped kalamata olives (to taste)
Have you ever visited this vibrant neighbourhood? It is located on Iran's Rainbow Island. Nader Khalili constructed this colourful house of earth domes, which is a beachfront housing complex.
Hormuz Island is located in the Persian Gulf, south of Iran, and is known as the "rainbow island" because of its colourful sand, which makes it a popular tourist destination. ZAV Architects developed a tiny town comprised of rainbow domes that overlap in unexpected combinations to provide houses and cultural activities such as laundry facilities, worship spaces, and a café in an effort to represent the colourful environment and terrain.
This multifunctional hamlet, known as Presence in Hormuz, is more than simply a bright and inviting refuge; it is the epitome of a paradigm change for the community. “The local people of the picturesque, touristy, and politically significant island suffer economically,” the architects add, “getting involved in criminal trafficking operations utilizing their boats.” This urban development initiative attempts to revitalize the local economy by using community people, both skilled and unskilled.
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Our inner conversation has a significant role in our well-being and happiness. Having nice things to say to oneself might help you live a more fulfilling life. The way we speak to ourselves internally has a significant impact on how we live, make decisions, and feel. A negative internal conversation can have a significant influence on our mental and emotional well-being, thus it is critical that we do not be too hard on ourselves on a regular basis.
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