Canadian researchers have discovered no evidence of cognitive effects in males being treated for metastatic, castration-resistant prostate cancer, or mCRPC, the most advanced form of prostate cancer. Following the failure of prior medications, the men were treated with one of four distinct therapies:
A chemotherapy drug called docetaxel
Enzalutamide is a second-generation hormonal therapy that is used when first-generation hormonal treatments fail.
Abiraterone is a second-generation hormonal therapy as well.
Radium-233, a radioactive isotope used to treat prostate cancer that has spread to the bones.
All of these drugs have been shown to prolong life, but published data on their cognitive side effects are limited, and no such data for docetaxel or radium-233 were available.
The researchers enlisted 155 men between the ages of 73 and 76, the majority of whom had completed some form of a college education. The cognitive functioning of the participants was assessed twice: once before the cancer treatments began and again after the treatments were completed (this amounted to six months for docetaxel and radium-233, and roughly 11 months for enzalutamide and abiraterone).
I grew up eating mangos not knowing that mango is a pricy fruit in some countries. Mangos are not only tasty but also have a lot of health benefits.
What are mangoes?
Mangos are a delicious delight that is rich in minerals, proteins, and carbs, whether you eat them whole or cut them into long or short pieces. Mango is one of the most fleshy fruits available. It might be small enough to fit in your hand or large enough to weigh more than a kilogram because it has hundreds of varieties. India, China, Thailand, and the Philippines continue to be the world's top producers of a wide range of mangos. People in these countries would slice them, soften and eat them, or use them to make delectable chutneys.
Interesting fact: The world's largest mango, which holds the Guinness World Record, is over 3.5 kilograms and hails from the Philippines.
Nutritional Values of Mangoes
Mangos are high in carbs, with an average-sized mango providing up to 15g of carbohydrates. A typical sized cup of sliced mango has approximately 100% of your daily vitamin C need. Vitamin A is another important nutrient present in mango. Calcium is the most common mineral, followed by manganese, magnesium, and iron. Zinc and sodium are also present in trace amounts. Thiamine, vitamin B6, folate, vitamin K, and vitamin E are some of the other vitamins you may get by eating a mango. Mangos have no cholesterol, therefore you shouldn't be concerned about your cholesterol levels when eating them. People frequently refer to them as superfoods or super fruits because of their diverse vitamin and mineral content.
Mangoes Have a Lot of Health Benefits.
The tasty fruit has several benefits for your skin, hair, eyes, immune system, and more!
1. Mangoes help in the enhancement of sexual life.
Vitamin E has an effect on a person's sexual desire. Your sexual desire will enhance if you have a well-balanced vitamin E level in your body. Beta-carotene and vitamin E, both present in mango, have been demonstrated in studies to improve the health of sperm in males. Eating mangos can also help to reduce sperm membrane oxidation.
2. Reduced Chances of Heart Disease.
When it comes to body fat and cholesterol control, mangos may be quite beneficial to your health. To begin with, you might consume them and feel satisfied without increasing your cholesterol levels. Mangos' satiating qualities will protect you from overindulging in calorie-dense meals that will make you gain weight. Mango phytochemicals can also help you lose weight by having a favourable influence on your body's fat. As a result of these benefits, you can avoid heart-related disorders and stay healthy.
Mangos are high in carbs, with an average-sized mango providing up to 15g of carbohydrates. A typical sized cup of sliced mango has approximately 100% of your daily vitamin C need. Vitamin A is another important nutrient present in mango. Calcium is the most common mineral, followed by manganese, magnesium, and iron. Zinc and sodium are also present in trace amounts. Thiamine, vitamin B6, folate, vitamin K, and vitamin E are some of the other vitamins you may get by eating a mango. Mangos have no cholesterol, therefore you shouldn't be concerned about your cholesterol levels when eating them. People frequently refer to them as superfoods or super fruits because of their diverse vitamin and mineral content.
Mangoes Have a Lot of Health Benefits.
The tasty fruit has several benefits for your skin, hair, eyes, immune system, and more!
1. Mangoes help in the enhancement of sexual life.
Vitamin E has an effect on a person's sexual desire. Your sexual desire will enhance if you have a well-balanced vitamin E level in your body. Beta-carotene and vitamin E, both present in mango, have been demonstrated in studies to improve the health of sperm in males. Eating mangos can also help to reduce sperm membrane oxidation.
2. Reduced Chances of Heart Disease.
When it comes to body fat and cholesterol control, mangos may be quite beneficial to your health. To begin with, you might consume them and feel satisfied without increasing your cholesterol levels. Mangos' satiating qualities will protect you from overindulging in calorie-dense meals that will make you gain weight. Mango phytochemicals can also help you lose weight by having a favourable influence on your body's fat. As a result of these benefits, you can avoid heart-related disorders and stay healthy.
3. A Bone Health Boost.
Mangos are high in vitamin A and C, making them ideal for bone health. Collagen is a protein that is essential for skin health as well as bone health. Collagen makes up the fibrous portion of the bones. While vitamin A is beneficial to bone health, too much of it can be harmful.
4. Improves and gives fairer skin.
Topical treatments to enhance your skin will never produce excellent effects unless you feed your body nutritious foods on the inside. Collagen is found in mangos. Collagen is the protein that gives your skin its elasticity and radiance. If you want to look your best, eat mangos. You may use mango for skin not just by eating it, but also by using one of the many mango masks available.
Mangos are high in vitamin A and C, making them ideal for bone health. Collagen is a protein that is essential for skin health as well as bone health. Collagen makes up the fibrous portion of the bones. While vitamin A is beneficial to bone health, too much of it can be harmful.
4. Improves and gives fairer skin.
Topical treatments to enhance your skin will never produce excellent effects unless you feed your body nutritious foods on the inside. Collagen is found in mangos. Collagen is the protein that gives your skin its elasticity and radiance. If you want to look your best, eat mangos. You may use mango for skin not just by eating it, but also by using one of the many mango masks available.
According to new research published in Science, metabolism peaks much earlier in life and slows much later than much later than we think. Before we delve into the specifics of the new research, it's necessary to establish a few terminology.
Metabolism is a term that refers to the collection of chemical process that enable an organism to live. This involves the conversion of energy from food into energy for life-sustaining processes such as breathing, circulating blood, growing and repairing cells, digesting food, and removing waste in humans.
The amount of energy required to carry out these essential processes while an organism is fasting or at rest is referred to as the basal metabolic rate, or BMR, and may be determined using a variety of online calculators that take an individual's height, weight, age, and gender into account. The term basal metabolic rate, or BMR, is frequently used interchangeably with resting metabolic rate, or RMR. Total energy expenditure (TEE) is calculated as the sum of BMR, energy used on physical activities, and energy spent on food digestion (known as dietary thermogenesis). BMR contributes for around 50% to 70% of total energy output in sedentary individuals, dietary thermogenesis accounts for 10% to 15%, and physical activity accounts for the remaining 20% to 30%.
Although we know that certain factors such as age, sex, body mass, body composition, physical activity, and illness all affect energy expenditure, the most recent comprehensive study, which included data from people worldwide, revealed surprising information about the timing of age-related metabolism changes throughout the lifespan.
The Italian Alps form an arc stretching from Monaco in the west to Trieste in the east, encompassing the entirety of Italy's northernmost region.
They are divided into three major categories. With its dramatic playground of snowcapped mountains, which borders France and Switzerland, the western side of the high Alps is the southern end of the high Alps. The Italian Lakes are located in the center of the country, where large lakes are surrounded by smaller hills and picturesque villages. The Dolomites, on the other hand, are jagged rocky peaks surrounded by lush alpine meadows in the eastern section.
From Milan, the entire Italian Alps region is easily accessible. When visiting the Dolomites in the eastern section, the best activities are only a short drive away from Venice or Verona in the south, or Innsbruck in the north, depending on where you are coming from in Italy or Austria.
1. Lake Braies by @elcampa1969
2. Molveno by @funk_design
3. Val Badia by @ilhan1077
4. Lake Braies by @rita_manzella_
5. Rifugio delle Odle by @elcampa1969
6. Val Badia by @ilhan1077
2. Molveno by @funk_design
3. Val Badia by @ilhan1077
4. Lake Braies by @rita_manzella_
5. Rifugio delle Odle by @elcampa1969
6. Val Badia by @ilhan1077
The most critical lifesaving tool we have in this pandemic is vaccination against the virus that causes COVID-19. All of the vaccines that have been licensed in the United States have been proven to be extremely safe and reliable. And we've known from the start that the robust protection they provide would eventually wane.
However, has protection deteriorated sufficiently to warrant booster shots? Recent studies published by researchers in the United Kingdom, Israel, and the United States (reviewed here and here) raised this possibility, and Israel and the United Kingdom have already launched ambitious booster programs.
Vaccinate every single person.
You might be aware, that the CDC and FDA conducted a review of the need, safety, and effectiveness of boosters for the Pfizer/BioNTech vaccine. In the coming weeks and months, both agencies will conduct a review of data for Moderna and Johnson & Johnson. This is the only booster shot available right now.
But first and foremost, it's critical not to overlook this fact: vaccinating the unvaccinated should take priority over booster shots for those who have already received vaccines. This is true for individuals in the United States who have been unable or unwilling to obtain the vaccine, as well as individuals in other parts of the world with limited access to vaccines.
Not only would expanding the pool of people who have received their initial vaccinations save more lives than promoting boosters, but it would also help reduce COVID-related healthcare disparities between richer and poorer countries. That is why the World Health Organization (WHO) has called for a moratorium on booster doses. Biden administration officials announced that an additional 500 million vaccines would be donated to developing countries with low vaccination rates, bringing the US commitment to 1.1 billion doses. The administration emphasizes that establishing a booster program in the United States and assisting other countries in vaccinating their citizens are not mutually exclusive.
Is a booster dose different from a third shot?
Not all additional vaccine doses are boosters. FDA approved a third dose in August 2021, the Pfizer or Moderna vaccine for immunocompromised individuals. This includes individuals living with HIV and those undergoing cancer treatment that suppresses the immune system. The extra dose is not considered a booster for them; it is considered part of their initial immunization series.
Choosing the right time to receive vaccine boosters
Ideally, vaccines booster are administered no sooner than necessary, but well before widespread protective immunity begins to decline. The dangers of waiting too long are self-evident: as immunity declines, infection, serious illness, and death rates may begin to rise.
However, there are downsides to administering boosters prematurely:
Side effects may be more common. While published research indicates that boosters are safe, we don’t yet have long-term data.
The benefit may be small. It may be advisable to wait on booster vaccinations if the majority of people are still protected by their initial vaccinations.
It's possible that current boosters won't cover future variants. Boosters may be modified to include new variants of concern in the coming months.
Pfizer/BioNTech vaccine booster recommendations
The CDC and FDA have concluded that boosters are necessary for some recipients of the Pfizer/BioNTech vaccine. A booster dose is recommended at least six months after the second dose for those who are :
- 65 years of age or older.
- 18 to 64 years of age and at a high risk of developing severe illness from COVID, such as those who have chronic lung disease, cancer, or diabetes.
- Residents of long-term care facilities, healthcare workers, teachers and daycare staff, grocery workers, and prisoners all work in high-exposure environments.
There are currently no Pfizer/BioNTech boosters recommended for the general population. This is because the initial doses continue to provide adequate protection against serious illness and death.
Countless unknowns
The publication of these new recommendations for Pfizer vaccine boosters raises several concerns:
How credible is the safety data? To date, reports indicate that boosters are safe, but additional research and real-world data are needed.
Moderna and Johnson & Johnson boosters are still awaiting FDA approval. When can we expect that?
Should all boosters contain the same vaccine as the initial regimen, or does mixing vaccines provide additional protection?
The unfortunate thing is that some people are combining vaccines on their own, sometimes by falsely stating they didn't get the COVID shot before getting a different kind of shot altogether.
Will booster doses be identical to initial doses? So far, the answer for the Pfizer/BioNTech vaccine has been affirmative. If the Moderna booster is authorized, it will very certainly be for a half-dose.
Will boosters be altered to protect against new variants?
Will there be a future need for additional boosters? If so, how frequently?
In the coming weeks and months, look for answers to these questions.
What is next?
Based on ongoing review and analysis of available research, the FDA and CDC are expected to revise and expand booster recommendations. Meanwhile, we should intensify our efforts to vaccinate those who have not received vaccines. Individuals can benefit significantly from boosters. However, as Dr. Rochelle Wallensky, director of the CDC, notes, "we will not boost our way out of this pandemic."
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